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Histologic preparation of hard tissue: Medical devices in tissue explants

Histopathology is the final and corner-stone assessment of all the medical devices tested at IMMR. Safety issues have indeed to be addressed at a microscopic level in a standardized and scrupulous manner. But histologic preparation of hard tissue specimens is not as routine as paraffin embedding. Teeth, bone, dental implants, coronary or aortic stents, screws, medical ceramic require that the tissue preparation be respectful of both the implantand the host tissue. The cutting and grinding technique is the gold standard in order to obtain thin sections of large specimens which cannot be processed by conventional techniques.

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