Week of 9 February 2021


Le cœur a ses raisons que la raison ne connaît point.

(Blaise Pascal, Pensées, 1669).

For a very long time, the connection between the heart and the brain was understood to be a master-servant relationship in which the brain would give orders to the heart and the latter would simply respond as directed. Recently, however, a deeper heart-brain connection has been recognized, relating cardiac events to emotional stress and even vice-versa. Indeed, in the last decades, emotional stress has been highlighted as a key risk factor for heart attacks. A recently discovered cardiac disease, the Takotsubo cardiomyopathy, also known as the Broken Heart Syndrome, is a perfect example of this heart-brain connection. It is defined as reversible ventricular dysfunction in the absence of coronary artery disease. One-third of affected patients cited sudden and clear emotional stress1. It is proposed that emotional stress leads to the activation of the sympathetic nervous system by the amygdala, stimulating the production of pro-inflammatory cells that may trigger heart attack, stroke, or sudden death2.

Sending you and your loved ones good cheer and best wishes for Valentine’s Day!

1Ghadri JR, et al: Long-Term Prognosis of Patients with Takotsubo Syndrome. J Am Coll Cardiol 2018 Aug 21;72(8):874-882.

2Miller M: Emotional Rescue: The Heart-Brain Connection. Cerebrum 2019 May 1;2019:cer-05-19.

HE&S, Original magnification: x20, Scale bar: 50 µm

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