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Enabling and accelerating
your innovative research with recognized
world-class experts.

We have unmatched expertise


in cardiovascular research, a space that demands a high technical standard.
In addition, we also regularly complete studies in ophthalmology, thoracic surgery, neurosurgery, orthopedics,
gastroenterology, dentistry, urology, fetal surgery and surgical robotics.
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State of the art surgical suites



IMMR offers a professional, hospital-environment technical platform to ensure a successful bridge from the preclinical to the clinical evaluation phase. We meet your preclinical research needs with cutting-edge technology:

• 2 Hybrid rooms with 3D rotational angiography suite by Philips

• 3 large ORs

After refurbishing our hosting and office area in 2012 and investing in a larger and improved husbandry facility (still ongoing), we invested in providing the most advanced 3D hybrid operating room on the market.

Being one of the most experienced labs in hybrid procedures for structural heart disease made it clear that we needed imaging that could address the critical questions of our customers with respect to anatomy and functionality.

We have made significant progress in our understanding of how best to approach valvular and vascular trans-catheter and hybrid therapies, and also how best to validate orthopedic and neurologic implants. We keep pace with the most recent advances in imaging because we believe this a central element of good research and it is also what clinicians will encounter in the clinical environment.

There is no doubt that compelling imaging also contributes to convincing your key stakeholders: fellow researchers, clinicians and investors.

We provide complete service with:

• Meeting rooms with live case capabilities

• Lecture halls and class rooms for the teaching sessions (up to 150 seats)

• Event-planning assistance, administrative support for arranging hotel accommodations, taxi or limousine service, and fine catering or VIP lunch boxes upon request.

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Imaging is one of the cornerstones of our daily practice at IMMR. We need to remain at the forefront of imaging just as we do for procedures for the advanced therapeutics and novel devices we test in relevant models.

Imaging is a cornerstone of IMMR activity in large model preclinical research. Non-destructive x-ray analysis of medical devices and tissue explants is also often essential and this requires high precision cabinet x-ray systems. Ex vivo x-ray imaging of explanted stents and valves is something we do frequently and so we also invested in the Faxitron MX-20 Radiography System, used in medical, forensic, scientific and agricultural applications. It provides on-the-spot images in seconds and can export in most formats. Never have we been so well equipped to get nondestructive information about calcification of biologic material and metallic device integrity.

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In IMMR’s well-equipped ORs and procedure rooms, feeds from two live cameras, angiography, ultrasound, hemodynamic monitoring and other imaging modalities such as endoscopy can be broadcast live into our adjacent conference rooms and also recorded in HD format (clients can go home with a flash drive with all raw data and the OR video). These capabilities have served our customers well for nearly the past 10 years. Thanks to IMMR’s commitment to keeping our facilities equipped with cutting edge capabilities, research teams can now also enjoy the benefit of being able to remotely see and hear in real time what is happening in the operating theater with our brand new and user-friendly interactive live broadcasting system. Invited participants can connect to their case happening in the IMMR OR from the comfort of their facility, lab, home office or conference room anywhere in the world. This unique system is purpose-built for surgical use, delivering multi-party HD video and turn-key interactivity, all in a secure, encrypted state-of-the-art web-platform never previously available.
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(latest generation)


Our laboratory stays at the fore-front of technology in many different medical and surgical fields of specialty, namely cardiovascular surgery and interventional cardiology, urology, GI surgery, neurology, orthopedics, dentistry, robotics. As for endoscopy we have recently made 3 acquisitions: three complete high end endoscopy towers.

These three towers (by Fuji and Olympus) are as state-of-the-art as it gets and come with everything needed for excellent imaging, noise reduction, excellent brightness and digital output. Many different kinds of endoscopes (gastrocopes, duodenoscopes, colonoscopes, etc.) can be connected to their different sockets.

These towers can be adapted for GI endoscopy of course, but just as well for bronchoscopy and otorhynolaryngology. We can use these towers in our preclinical platform for early R&D, GLP studies, physician training.

Videoscopic columns (3CCD and full HD digital with digital recording on flash drive)

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IMMR strives to operate according to
the highest existing standards of quality.

In addition to conducting scientific and medical device projects for human research, we have also been performing clinical veterinary cardiovascular surgery and interventional cardiology for more than 20 years. This is the result of a long-standing partnership between IMMR and Pr Valérie Chetboul with the Cardiology Unit of the Maisons-Alfort Veterinary School near Paris. Ever since, we operate on veterinary patients with cardiovascular conditions, place pacemakers for conduction tissue abnormalities and implant surgical or trans-catheter valves for structural heart disease, etc. In a nutshell, we leverage the technical platform and know-how of IMMR to treat cats and dogs – and the occasional exotic animal - with spontaneous heart disease. Some of these achievements were published in peer-reviewed scientific journals and are accessible here…

Lavennes M, Chetboul V, Passavin P, Gouni V, Damoiseaux C, Poissonnier C, Carazo Arias LE, Alvarado MP, Morlet A, Chevènement O, Behr L, Borenstein N. Successful transcatheter retrieval of embolized Amplatz Canine Duct Occluders in two dogs. J Vet Cardiol. 2018 Dec;20(6):451-457.

Chetboul V, Damoiseaux C, Behr L, Morlet A, Moise NS, Gouni V, Lavennes M, Pouchelon JL, Laborde F, Borenstein N. Intracardiac echocardiography: use during transcatheter device closure of a patent ductus arteriosus in a dog. J Vet Cardiol. 2017 Jun;19(3):293-298.

Borenstein N, Gouni V, Behr L, Trehiou-Sechi E, Petit A, Misbach C, Raillard M, Retortillo JL, Pouchelon JL, Pierrel A, Laborde F, Chetboul V. Surgical Treatment of Cor Triatriatum Sinister in a Cat Under Cardiopulmonary Bypass. Vet Surg. 2015 Nov;44(8):964-9. doi: 10.1111/vsu.12403. Epub 2015 Sep 28. Erratum in: Vet Surg. 2016 Apr;45(3):406.

Trehiou-Sechi E, Behr L, Chetboul V, Pouchelon JL, Castaignet M, Gouni V, Misbach C, Petit AM, Borenstein N. Echoguided closed commissurotomy for mitral valve stenosis in a dog. J Vet Cardiol. 2011 Sep;13(3):219-25.

de La Villeon G, Louvet A, Behr L, Borenstein N. Transcatheter glue arterialembolization of a mass in the hind limb of a dog. Can Vet J. 2011 Mar;52(3):289-94.

Chai N, Behr L, Chetboul V, Pouchelon JL, Wedlarski R, Tréhiou-Sechi E, Gouni V, Misbach C, Petit AM, Bourgeois A, Hazan T, Borenstein N. Successful treatment of a congenital pulmonic valvular stenosis in a snow leopard (Uncia uncia) by percutaneous balloon valvuloplasty. J Zoo Wildl Med. 2010 Dec;41(4):735-8.

Behr L, Chetboul V, Sampedrano CC, Vassiliki G, Pouchelon JL, Laborde F, Borenstein N. Beating heart mitral valve replacement with a bovine pericardial bioprosthesis for treatment of mitral valve dysplasia in a Bull Terrier. Vet Surg. 2007 Apr;36(3):190-8.

“We are not a veterinary clinic and our primary mission is indeed to validate medical devices and novel therapeutic strategies in clinically relevant large animal preclinical models. However, it is important to us to dedicate time and resources to restoring health to pets and other animals with complex conditions. After nearly 20 years of a close and fruitful collaboration between the Veterinary School of Maisons-Alfort near Paris and IMMR, we regularly perform surgical or percutaneous patent ductus arteriosus closure, balloon dilatation of pulmonic stenosis, pacemaker implantation, and valvular replacement under cardiopulmonary bypass. We have the technical platform, the know-how and the wish to apply those techniques to veterinary patients. There are only a handful of veterinary teams worldwide that perform such interventions. It is for us a meaningful way to give back to animals for what they have given to help advance human health over the years.”

Dr Nicolas Borenstein, DVM, PhD

 Borenstein N, Behr L, Chetboul V, Tessier D, Nicole A, Jacquet J, Carlos C, Retortillo J, Fayolle P, Pouchelon JL, Daniel P, Laborde F. Minimally invasive patent ductus arteriosus occlusion in 5 dogs. Vet Surg. 2004Jul-Aug;33(4):309-13. a

Borenstein N, Daniel P, Behr L, Pouchelon JL, Carbognani D, Pierrel A, Macabet V, Lacheze A, Jamin G, Carlos C, Chetboul V, Laborde F. Successful surgical treatment of mitral valve stenosis in a dog. Vet Surg. 2004 Mar-Apr;33(2):138-45.

François L, Chetboul V, Nicolle A, Carlos C, Borenstein N, Pouchelon JL. [Pacemaker implantation in dogs: results of the last 30 years]. Schweiz Arch Tierheilkd. 2004 Jul;146(7):335-44. French.

Nicolle A, Borenstein N, Tessier Vetzel D, Rouby M, Behr L, Pouchelon JL, Chetboul V. [Exploration of a third-degree atrioventricular block by standard echocardiography, tissue Doppler imaging, and treatment with a cardiac pacemaker in a German wire-haired pointer]. Schweiz Arch Tierheilkd. 2004 Feb;146(2):81-7.